Washington University in St Louis

The Preston M. Green Department of
Electrical & Systems Engineering

We build novel imaging technologies

Lew Lab group photo

The Lew Lab leverages innovations in applied physics, electrical engineering, computational algorithms, and chemistry to create optical imaging systems with unprecedented performance. We partner with scientists and engineers across all disciplines to develop technologies to solve unmet needs in science, medicine, and society.

The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology. Meet the members of this team. Excited about joining our team?

Creating impactful technology is our passion

Comparing conventional microscopy with super-resolved nanoscopy

One of our goals is to develop advanced nanoscopes (microscopes with nanometer resolution) that can visualize the activity of molecular machines inside and between living cells. These tools would allow researchers to observe a variety of processes involved in health and disease: viruses invading cells, cells packaging biomolecular cargo to communicate with other cells, and much more. The nanoscopes we build enable us to see activities in the molecular world within living cells that could never be seen before.

Lab news

Oumeng's article on the Tri-spot point spread function is now online at Applied Physics Letters. Congratulations to the entire team! Read it here:
“Imaging the three-dimensional orientation and rotational mobility of fluorescent emitters using the Tri-spot point spread function”

Super-Resolution Imaging of Amyloid Structures over Extended Times Using Transient Binding of Single Thioflavin T MoleculesKevin's and Tianben's article on super-resolution transient amyloid binding (TAB) microscopy is now online at ChemBioChem. Congratulations to the entire team! Read it here:
“Super-Resolution Imaging of Amyloid Structures over Extended Times Using Transient Binding of Single Thioflavin T Molecules”

Matt gave an invited Stanford Optical Society seminar entitled “Computational Optics for Multidimensional Nanoscale Imaging of Single Fluorescent Molecules.”
Matt Stanford OSA seminar 2018