Washington University in St Louis

The Preston M. Green Department of
Electrical & Systems Engineering

We build novel imaging technologies

Lew Lab group photo

The Lew Lab leverages innovations in applied physics, electrical engineering, computational algorithms, and chemistry to create optical imaging systems with unprecedented performance. We partner with scientists and engineers across all disciplines to develop technologies to solve unmet needs in science, medicine, and society.

The Lew Lab is a team of inventors, thinkers, and problem solvers working at the intersection of science and technology. Meet the members of this team. Excited about joining our team?

Creating impactful technology is our passion

Comparing conventional microscopy with super-resolved nanoscopy

One of our goals is to develop advanced nanoscopes (microscopes with nanometer resolution) that can visualize the activity of molecular machines inside and between living cells. These tools would allow researchers to observe a variety of processes involved in health and disease: viruses invading cells, cells packaging biomolecular cargo to communicate with other cells, and much more. The nanoscopes we build enable us to see activities in the molecular world within living cells that could never be seen before.

Lab news

Jack Hyde, who is majoring in Electrical Engineering, has joined the Lew Lab. He has received a Summer Undergraduate Research Award from the Office of Undergraduate Research. Welcome, Jack!
Jack Hyde

Kevin Spehar, who is majoring in Biomedical Engineering, has joined the Lew Lab. Welcome, Kevin!
Kevin Spehar

Hesam and Oumeng gave excellent presentations at SPIE BiOS (Photonics West). See them here:
“A robust statistical estimation (RoSE) algorithm jointly recovers the 3D location and intensity of single molecules accurately and precisely”
“Measuring 3D molecular orientation and rotational mobility using a Tri-spot point spread function”